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Hello Rene,

Yo need to create wildCard subdomain into cPanel. *.mydomain.com
and all accounts on subdomains will work.

If you want to activate/deactivate users on subdomains you can do it in...

Go to Admin Panel >> Account Types click edit icon and find lines:
Generate individual pages for users of this type.
Build URLs of individual pages in subdirectories.
both should be selected.